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November 21.2025

2 Minutes Read

Mis-Prescribing of PPIs: Are You Taking Unnecessary Risks?

Brightly colored capsules spilled on a pink surface, symbolizing mis-prescribed PPIs.

Why Are So Many Prescriptions Misguided?

The crucial question arises: Why are millions of individuals prescribed proton pump inhibitors (PPIs) without adequate diagnostic testing? A recent survey by The Functional Gut Clinic revealed a staggering statistic—92% of respondents had not undergone testing to confirm gastro-oesophageal reflux disease (GORD), even though approximately 10 million people in the UK are prescribed these drugs. With such a high percentage of patients receiving treatment based solely on symptoms, a misdiagnosis appears painfully common.

The Dangers of Prolonged PPI Use

Long-term use of PPIs is not without its complications. Overuse can disrupt the delicate balance of the gut microbiome, impair nutrient absorption, and mask underlying health issues that could escalate over time. Professor Anthony Hobson from The Functional Gut Clinic notes, "Patients describe years of symptoms with minimal specialist intervention and indefinite PPI use—sometimes for decades." This type of medical practice, where prescription precedes diagnosis, can lead to serious ramifications for patients' overall well-being.

Current Problems in GORD Diagnosis

Despite widespread prescribing practices, access to NHS gastroenterology services remains limited. A third of the participants in the survey had never seen a gastroenterologist, highlighting a significant access barrier. Even more troubling, proper diagnostic tests like pH monitoring—a key step in confirming acid reflux—were performed on only 8% of respondents.

Recommendations for Better Care

In light of these findings, experts are calling for a reevaluation of how GORD is diagnosed and treated. Dr. Philip Woodland, a Consultant Gastroenterologist, emphasizes the need for improved understanding in primary care regarding treatment alternatives, such as dietary changes and avoiding known triggers. He suggests not just drug treatments but also behavioral interventions as effective options to consider before reaching for medications like PPIs.

Looking Forward

With the increasing awareness of the potential risks associated with long-term PPI use, there is a pressing need for the NHS to reassess its prescribing practices. Focusing more on proper diagnostic processes and considering non-drug interventions can contribute to better health outcomes and potentially safe hundreds of thousands from unnecessary medication.

Understanding the broader impacts of PPI prescriptions is essential not just for patients, but for healthcare providers aiming to provide the best care. It is time to ensure that treatment is based on facts, not assumptions.

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Mis-Prescribing of PPIs: Are You Taking Unnecessary Risks?

Why Are So Many Prescriptions Misguided?

The Dangers of Prolonged PPI Use

Current Problems in GORD Diagnosis

Recommendations for Better Care

Looking Forward

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